Platelets in sepsis: beyond hemostasis

3893 Platelets to hemostasis and beyond - - - - - - - -

The relevance of myeloid cells (bone marrow– derived cells or BMDCs) and platelets to tumor growth has long been recognized but that both are mechanistically linked is the latest information that expands the relevance of platelets beyond their traditional role in hemostasis and thrombosis.1,2 The late Judah Folkman pioneered the idea that growing solid tumors required active angiogenesis and me...

Beyond hemostasis: the role of platelets in inflammation, malignancy and infection.

Platelets play a complex role in hemostasis and thrombosis. The expression of multiple membrane receptors, both constitutive and activation-dependent, mediates platelet adhesion and aggregation at sites of vascular lesion. Platelet activation leads to exocytosis of granular constituents, release of newly synthesized mediators, and discharge of membrane-bound transcellular signaling molecules. M...

The Traditional Role of Platelets in Hemostasis

PLATELET DISORDERS Platelets in sepsis

Platelets are circulating blood cells that will normally not interact with the intact vessel wall but that may swiftly respond to vascular disruption by adhering to subendothelial structures, followed by interaction with each other, thereby forming a platelet aggregate. The activated platelet (phospholipid) membrane may form a suitable surface on which further coagulation activation may occur. ...

Platelets: crossroads of immunity and hemostasis.

In this issue of Blood, Koupenova and colleagues report that platelets express functional TOLL-like receptor 7 (TLR7) and contribute to host survival during viral infection. Through a series of experiments utilizing mice deficient for TLR7 together with adoptive transfer of wild-type platelets, Koupenova et al demonstrate that platelets specifically respond to viral analogs and intact virus, le...